S55746 hydrochloride ( BCL201;BCL-201;S 55746;S-55746;Servier-1 )

Catalog No. M11922 CAS No. 1448525-91-4

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Product Name

S55746 hydrochloride
Note

Research use only, not for human use.
Brief Description

S55746 (BCL201, Servier-1) is a novel potent, selective, orally bioavailable inhibitor of BCL-2 with Ki of 1.3 nM.
Description

S55746 (BCL201, Servier-1) is a novel potent, selective, orally bioavailable inhibitor of BCL-2 with Ki of 1.3 nM, 70- 400 fold selectivity over BCL-XL, on significant binding to MCL-1 and BFL-1; potently induces RS4;11 cell killing after 72 h of treatment with an IC50 of 71.6 nM, exhibits a much weaker activity in H146 (IC50 1.7 μM), a BCL-XL-dependent cell line; concentration-dependently disrupts the BCL-2/BAX complex in RS4;11 cells, selectively induces apoptosis through BCL-2 inhibition in a BAX/BAK-dependent manner; induces cell death in a panel of non-Hodgkin lymphoma cells; inhibits xenograft growth in RS4;11 and Toledo models.Blood Cancer Phase 1 Clinical
Synonyms

BCL201;BCL-201;S 55746;S-55746;Servier-1
Pathway

Angiogenesis
Target

Bcl-2
Recptor

Bcl-2
Research Area

Cancer
Indication

Blood cancer

CAS Number

1448525-91-4
Formula Weight

747.29
Molecular Formula

C43H43ClN4O6
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=C2CCCCN2C(C3=C(C(N4CC5=C(C=CC=C5)C[C@H]4CN6CCOCC6)=O)C=C(OCO7)C7=C3)=C1)N(C8=CC=C(O)C=C8)C9=CC=CC=C9.Cl
Chemical Name

N-(4-Hydroxyphenyl)-3-[6-[(3S)-3-(morpholinomethyl)-3,4-dihydro-1H-isoquinoline2-carbonyl]-1,3-benzodioxol-5-yl]-N-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide hydrochloride

1. Casara P, et al. Oncotarget. 2018 Apr 13;9(28):20075-20088.

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